Aneugenic Activity of Op18/Stathmin Is Potentiated by the Somatic Q18→E Mutation in Leukemic Cells
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چکیده
منابع مشابه
Aneugenic activity of Op18/stathmin is potentiated by the somatic Q18-->e mutation in leukemic cells.
Op18/stathmin (Op18) is a phosphorylation-regulated microtubule destabilizer that is frequently overexpressed in tumors. The importance of Op18 in malignancy was recently suggested by identification of a somatic Q18-->E mutation of Op18 in an adenocarcinoma. We addressed the functional consequences of aberrant Op18 expression in leukemias by analyzing the cell cycle of K562 cells either deplete...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2006
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e06-02-0165